In such patients, prothrombin time should be determined before starting simvastatin and frequently enough during early therapy to ensure that no significant alteration of prothrombin time occurs. A meta-analysis of large randomized clinical trials." J Cardiovasc Pharmacol 40 (2002): 163-71, 15. … Arch Intern Med 161 (2001): 1456-7, 33. In these studies, the side effects that occur in a group of people taking the drug are documented and are then compared to side effects that occur in another group of people not taking the medicine. Because the below reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Pedersen TR, Berg K, Cook TJ, Faergeman O, Haghfelt T, Kjekshus J, Miettinen T, Musliner TA, Olsson AG, Pyorala K, Thorgeirsso "Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the scandinavian simvastatin survival study." Myopathy is defined as any abnormal condition or disease of the muscle tissues, commonly involving skeletal tissue. breakdown. Zocor can cause mild or serious side effects. Am J Gastroenterol 87 (1992): 257. Morales K, Wittink M, Datto C, et al. McDonagh J, Winocour P, Walker DJ "Musculoskeletal manifestations during simvastatin therapy." Bjerre LM, LeLorier J "Do statins cause cancer? levels of the "good," or HDL cholesterol, may protect against narrowing of the Simvastatin therapy has not been associated with bleeding or with changes in prothrombin time in patients not taking anticoagulants. Gonyeau MJ "Statins and osteoporosis: a clinical review." Patients taking digoxin should be monitored appropriately when simvastatin is initiated. Further information. Diaczok BJ, Shali R "Statins unmasking a mitochondrial myopathy: a case report and proposed mechanism of disease." Am J Med 110 (2001): 716-23, 59. The incidence of myopathy, including rhabdomyolysis, was highest during the first year and then notably decreased during the subsequent years of treatment. Pharmacotherapy 25 (2005): 228-43, 28. Federman DG, Hussain F, Walters AB "Fatal rhabdomyolysis caused by lipid-lowering therapy." Ann Pharmacother 36 (2002): 288-95, 24. Simvastatin shares side effects, such as liver and muscle damage Contact your doctor if you have severe side effects of Zocor including: confusion, Gregoor PJ "Atorvastatin may cause nightmares." These cognitive issues have been reported for all statins. Because of the risk of adverse effects to the developing infant, Zocor should not be administered to breastfeeding mothers. What drugs interact with Zocor (simvastatin)? Are Statin Side Effects 'All in Your Head'? Simvastatin is metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is not expected to affect the plasma concentrations of other drugs metabolized by CYP3A4. When diet and exercise aren't enough, should you turn to drugs? And, since the drug itself turns off a vital function of the liver, it is important to understand that it is this very thing that could cause some of the side effects, such as Zocor liver side effects. Br J Rheumatol 32 (1993): 647-8, 11. Concomitant use of drugs labeled as having a strong inhibitory effect on CYP3A4 is contraindicated. Serious side effects and their symptoms can include: Liver problems, such as elevated levels of liver enzymes (proteins). Side effects reported by some people include muscle pain and digestive problems. Newman TB, Hulley SB "Carcinogenicity of lipid-lowering drugs." [Ref], Persistent elevations in transaminases of up to 3 times the upper limit of normal (3xULN) have been reported in 1% of patients. Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection." About 5% of patients had elevations of CK levels of 3 or more times the normal value on one or more occasions. What Should Cholesterol Levels Be After Heart Attack? Graham DJ, Staffa JA, Shatin D, et al. Other fibrates: Caution should be used when prescribing with simvastatin. atorvastatin (Lipitor) vs. simvastatin (Zocor), Zocor (simvastatin) vs. Crestor (rosuvastatin), increases in HbA1c and fasting serum glucose levels as are seen in.
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